Shea Andrews, PhD

Assistant Adjunct Professor
Psychiatry

Dr. Andrews is a genetic epidemiologist looking at the role of genetic and environmental risk factors in Alzheimer's disease. The Andrews Lab focuses on determining the causal pathways that underly the development of Alzheimer’s disease and related dementias (ADRD) by applying statistical genetic and genetic epidemiological approaches to large genetic & phenotypic datasets. Currently funded NIH-NIA and Alzheimer’s Association projects include (1) identifying causal risk factors for ADRD using genetic correlations, polygenic risk scores, and mendelian randomization; (2) understanding the role of mitochondrial genomics in ADRD pathogenesis; and (3) evaluating ancestry specific effects of AD genetic variants on AD endophenotypes.

Publications: 

Snoring and risk of dementia: a prospective cohort and Mendelian randomization study.

Sleep

Gao Y, Andrews S, Daghlas I, Brenowitz WD, Raji CA, Yaffe K, Leng Y

Dementia risk scores, apolipoprotein E, and risk of Alzheimer's disease: One size does not fit all.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Andrews SJ, Boeriu AI, Belloy ME, Renton AE, Fulton-Howard B, Brenowitz WD, Yaffe K, Alzheimer's Disease Neuroimaging Initiative

Causal Associations of Sleep Apnea With Alzheimer Disease and Cardiovascular Disease: A Bidirectional Mendelian Randomization Analysis.

Journal of the American Heart Association

Cavaillès C, Andrews SJ, Leng Y, Chatterjee A, Daghlas I, Yaffe K

Modifiable risk factors, APOE and risk of Alzheimer disease: one size does not fit all.

medRxiv : the preprint server for health sciences

Andrews SJ, Belloy ME, Renton AE, Fulton-Howard B, Brenowitz WD, Yaffe K, Alzheimer’s Disease Neuroimaging Initiative

Proteomics identifies potential immunological drivers of postinfection brain atrophy and cognitive decline.

Nature aging

Duggan MR, Peng Z, Sipilä PN, Lindbohm JV, Chen J, Lu Y, Davatzikos C, Erus G, Hohman TJ, Andrews SJ, Candia J, Tanaka T, Joynes CM, Alvarado CX, Nalls MA, Cordon J, Daya GN, An Y, Lewis A, Moghekar A, Palta P, Coresh J, Ferrucci L, Kivimäki M, Walker KA

Disentangling the causal effects of education and participation bias on Alzheimer's disease using Mendelian Randomization.

medRxiv : the preprint server for health sciences

Chatterjee A, Cavaillès C, Davies NM, Yaffe K, Andrews SJ

Visual Impairment, Eye Conditions, and Diagnoses of Neurodegeneration and Dementia.

JAMA network open

Ferguson EL, Thoma M, Buto PT, Wang J, Glymour MM, Hoffmann TJ, Choquet H, Andrews SJ, Yaffe K, Casaletto K, Brenowitz WD

The Role of Genomic-Informed Risk Assessments in Predicting Dementia Outcomes.

medRxiv : the preprint server for health sciences

Andrews SJ, Jonson C, Fulton-Howard B, Renton AE, Yokoyama JS, Yaffe K, Alzheimer’s Disease Neuroimaging Initiative

APOE Genotype and Alzheimer Disease Risk Across Age, Sex, and Population Ancestry.

JAMA neurology

Belloy ME, Andrews SJ, Le Guen Y, Cuccaro M, Farrer LA, Napolioni V, Greicius MD

Causal Associations of Sleep Apnea with Alzheimer's Disease and Cardiovascular Disease: a Bidirectional Mendelian Randomization Analysis.

medRxiv : the preprint server for health sciences

Cavaillès C, Andrews SJ, Leng Y, Chatterjee A, Daghlas I, Yaffe K

Snoring and risk of dementia: a prospective cohort and Mendelian randomization study.

medRxiv : the preprint server for health sciences

Gao Y, Andrews S, Brenowitz W, Raji CA, Yaffe K, Leng Y

Blood-Based Transcriptomic Biomarkers Are Predictive of Neurodegeneration Rather Than Alzheimer's Disease.

International journal of molecular sciences

Shvetcov A, Thomson S, Spathos J, Cho AN, Wilkins HM, Andrews SJ, Delerue F, Couttas TA, Issar JK, Isik F, Kaur S, Drummond E, Dobson-Stone C, Duffy SL, Rogers NM, Catchpoole D, Gold WA, Swerdlow RH, Brown DA, Finney CA

Genetic associations with age at dementia onset in the PSEN1 E280A Colombian kindred.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Cochran JN, Acosta-Uribe J, Esposito BT, Madrigal L, Aguill?n D, Giraldo MM, Taylor JW, Bradley J, Fulton-Howard B, Andrews SJ, Acosta-Baena N, Alzate D, Garcia GP, Piedrahita F, Lopez HE, Anderson AG, Rodriguez-Nunez I, Roberts K, Absher D, Myers RM, Beecham GW, Reitz C, Rizzardi LF, Fernandez MV, Goate AM, Cruchaga C, Renton AE, Lopera F, Kosik KS

The complex genetic architecture of Alzheimer's disease: novel insights and future directions.

EBioMedicine

Andrews SJ, Renton AE, Fulton-Howard B, Podlesny-Drabiniok A, Marcora E, Goate AM

Microglial efferocytosis: Diving into the Alzheimer's disease gene pool.

Neuron

Romero-Molina C, Garretti F, Andrews SJ, Marcora E, Goate AM

The role of mitochondrial genome abundance in Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Harerimana NV, Paliwali D, Romero-Molina C, Bennett DA, Pa J, Goate A, Swerdlow RH, Andrews SJ

Sex differences in the genetic architecture of cognitive resilience to Alzheimer's disease.

Brain : a journal of neurology

Eissman JM, Dumitrescu L, Mahoney ER, Smith AN, Mukherjee S, Lee ML, Scollard P, Choi SE, Bush WS, Engelman CD, Lu Q, Fardo DW, Trittschuh EH, Mez J, Kaczorowski CC, Hernandez Saucedo H, Widaman KF, Buckley RF, Properzi MJ, Mormino EC, Yang HS, Harrison TM, Hedden T, Nho K, Andrews SJ, Tommet D, Hadad N, Sanders RE, Ruderfer DM, Gifford KA, Zhong X, Raghavan NS, Vardarajan BN, Alzheimer’s Disease Neuroimaging Initiative (ADNI), Alzheimer’s Disease Genetics Consortium (ADGC), A4 Study Team, Pericak-Vance MA, Farrer LA, Wang LS, Cruchaga C, Schellenberg GD, Cox NJ, Haines JL, Keene CD, Saykin AJ, Larson EB, Sperling RA, Mayeux R, Cuccaro ML, Bennett DA, Schneider JA, Crane PK, Jefferson AL, Hohman TJ

A Mitochondrial DNA Haplogroup Defines Patterns of Five-Year Cognitive Change.

Journal of Alzheimer's disease : JAD

Watts A, Chalise P, Hu J, Hui D, Pa J, Andrews SJ, Michaelis EK, Swerdlow RH

Integrative metabolomics-genomics approach reveals key metabolic pathways and regulators of Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Horgusluoglu E, Neff R, Song WM, Wang M, Wang Q, Arnold M, Krumsiek J, Galindo-Prieto B, Ming C, Nho K, Kastenmüller G, Han X, Baillie R, Zeng Q, Andrews S, Cheng H, Hao K, Goate A, Bennett DA, Saykin AJ, Kaddurah-Daouk R, Zhang B, Alzheimer's Disease Neuroimaging Initiative (ADNI), Alzheimer Disease Metabolomics Consortium

Genome-wide association study and functional validation implicates JADE1 in tauopathy.

Acta neuropathologica

Farrell K, Kim S, Han N, Iida MA, Gonzalez EM, Otero-Garcia M, Walker JM, Richardson TE, Renton AE, Andrews SJ, Fulton-Howard B, Humphrey J, Vialle RA, Bowles KR, de Paiva Lopes K, Whitney K, Dangoor DK, Walsh H, Marcora E, Hefti MM, Casella A, Sissoko CT, Kapoor M, Novikova G, Udine E, Wong G, Tang W, Bhangale T, Hunkapiller J, Ayalon G, Graham RR, Cherry JD, Cortes EP, Borukov VY, McKee AC, Stein TD, Vonsattel JP, Teich AF, Gearing M, Glass J, Troncoso JC, Frosch MP, Hyman BT, Dickson DW, Murray ME, Attems J, Flanagan ME, Mao Q, Mesulam MM, Weintraub S, Woltjer RL, Pham T, Kofler J, Schneider JA, Yu L, Purohit DP, Haroutunian V, Hof PR, Gandy S, Sano M, Beach TG, Poon W, Kawas CH, Corrada MM, Rissman RA, Metcalf J, Shuldberg S, Salehi B, Nelson PT, Trojanowski JQ, Lee EB, Wolk DA, McMillan CT, Keene CD, Latimer CS, Montine TJ, Kovacs GG, Lutz MI, Fischer P, Perrin RJ, Cairns NJ, Franklin EE, Cohen HT, Raj T, Cobos I, Frost B, Goate A, White Iii CL, Crary JF

A globally diverse reference alignment and panel for imputation of mitochondrial DNA variants.

BMC bioinformatics

McInerney TW, Fulton-Howard B, Patterson C, Paliwal D, Jermiin LS, Patel HR, Pa J, Swerdlow RH, Goate A, Easteal S, Andrews SJ, for the Alzheimer?s Disease Neuroimaging Initiative

Mitochondrial pathway polygenic risk scores are associated with Alzheimer's Disease.

Neurobiology of aging

Paliwal D, McInerney TW, Pa J, Swerdlow RH, Easteal S, Andrews SJ, Alzheimer's Disease Neuroimaging Initiative

Mapping the human genetic architecture of COVID-19.

Nature

COVID-19 Host Genetics Initiative

Shared genetic etiology between idiopathic pulmonary fibrosis and COVID-19 severity.

EBioMedicine

Fadista J, Kraven LM, Karjalainen J, Andrews SJ, Geller F, COVID-19 Host Genetics Initiative, Baillie JK, Wain LV, Jenkins RG, Feenstra B

The variant call format provides efficient and robust storage of GWAS summary statistics.

Genome biology

Lyon MS, Andrews SJ, Elsworth B, Gaunt TR, Hemani G, Marcora E

Causal Associations Between Modifiable Risk Factors and the Alzheimer's Phenome.

Annals of neurology

Andrews SJ, Fulton-Howard B, O'Reilly P, Marcora E, Goate AM, collaborators of the Alzheimer's Disease Genetics Consortium

Genetic variants and functional pathways associated with resilience to Alzheimer's disease.

Brain : a journal of neurology

Dumitrescu L, Mahoney ER, Mukherjee S, Lee ML, Bush WS, Engelman CD, Lu Q, Fardo DW, Trittschuh EH, Mez J, Kaczorowski C, Hernandez Saucedo H, Widaman KF, Buckley R, Properzi M, Mormino E, Yang HS, Harrison T, Hedden T, Nho K, Andrews SJ, Tommet D, Hadad N, Sanders RE, Ruderfer DM, Gifford KA, Moore AM, Cambronero F, Zhong X, Raghavan NS, Vardarajan B, Alzheimer’s Disease Neuroimaging Initiative (ADNI), Alzheimer’s Disease Genetics Consortium (ADGC), A4 Study Team, Pericak-Vance MA, Farrer LA, Wang LS, Cruchaga C, Schellenberg G, Cox NJ, Haines JL, Keene CD, Saykin AJ, Larson EB, Sperling RA, Mayeux R, Bennett DA, Schneider JA, Crane PK, Jefferson AL, Hohman TJ

Exploratory analysis of mtDNA haplogroups in two Alzheimer's longitudinal cohorts.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Swerdlow RH, Hui D, Chalise P, Sharma P, Wang X, Andrews SJ, Pa J, Mahnken JD, Morris J, Wilkins HM, Burns JM, Michaelis ML, Michaelis EK, Alzheimer's Disease Neuroimaging Initiative (ADNI)

Interpretation of risk loci from genome-wide association studies of Alzheimer's disease.

The Lancet. Neurology

Andrews SJ, Fulton-Howard B, Goate A

Association between alcohol consumption and Alzheimer's disease: A Mendelian randomization study.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Andrews SJ, Goate A, Anstey KJ

Investigation of antihypertensive class, dementia, and cognitive decline: A meta-analysis.

Neurology

Peters R, Yasar S, Anderson CS, Andrews S, Antikainen R, Arima H, Beckett N, Beer JC, Bertens AS, Booth A, van Boxtel M, Brayne C, Brodaty H, Carlson MC, Chalmers J, Corrada M, DeKosky S, Derby C, Dixon RA, Forette F, Ganguli M, van Gool WA, Guaita A, Hever AM, Hogan DB, Jagger C, Katz M, Kawas C, Kehoe PG, Keinanen-Kiukaanniemi S, Kenny RA, K?hler S, Kunutsor SK, Laukkanen J, Maxwell C, McFall GP, van Middelaar T, Moll van Charante EP, Ng TP, Peters J, Rawtaer I, Richard E, Rockwood K, Ryd?n L, Sachdev PS, Skoog I, Skoog J, Staessen JA, Stephan BCM, Sebert S, Thijs L, Trompet S, Tully PJ, Tzourio C, Vaccaro R, Vaaramo E, Walsh E, Warwick J, Anstey KJ

Mitonuclear interactions influence Alzheimer's disease risk.

Neurobiology of aging

Andrews SJ, Fulton-Howard B, Patterson C, McFall GP, Gross A, Michaelis EK, Goate A, Swerdlow RH, Pa J, Alzheimer's Disease Neuroimaging Initiative

Mitochondria and Alzheimer's: Is PTCD1 the Smoking Gun?

Trends in neurosciences

Pa J, Andrews SJ, Swerdlow RH

Alzheimer's Environmental and Genetic Risk Scores are Differentially Associated With General Cognitive Ability and Dementia Severity.

Alzheimer disease and associated disorders

Andrews SJ, McFall GP, Dixon RA, Cherbuin N, Eramudugolla R, Anstey KJ

Protective Variants in Alzheimer's Disease.

Current genetic medicine reports

Andrews SJ, Fulton-Howard B, Goate A

Association of Alzheimer's Disease Genetic Risk Loci with Cognitive Performance and Decline: A Systematic Review.

Journal of Alzheimer's disease : JAD

Andrews SJ, McFall GP, Booth A, Dixon RA, Anstey KJ

Association of Alzheimer's genetic loci with mild behavioral impairment.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics

Andrews SJ, Ismail Z, Anstey KJ, Mortby M

Memory Resilience to Alzheimer's Genetic Risk: Sex Effects in Predictor Profiles.

The journals of gerontology. Series B, Psychological sciences and social sciences

McDermott KL, McFall GP, Andrews SJ, Anstey KJ, Dixon RA

Late Onset Alzheimer's Disease Risk Variants in Cognitive Decline: The PATH Through Life Study.

Journal of Alzheimer's disease : JAD

Andrews SJ, Das D, Anstey KJ, Easteal S

Association of genetic risk factors with cognitive decline: the PATH through life project.

Neurobiology of aging

Andrews SJ, Das D, Cherbuin N, Anstey KJ, Easteal S

Interactive effect of APOE genotype and blood pressure on cognitive decline: the PATH through life study.

Journal of Alzheimer's disease : JAD

Andrews S, Das D, Anstey KJ, Easteal S